#1 - Fullmetal Alchemist
Chances are, you know who this is about but I'll stick to my non-spoiler creed.
#1 - Edward and Winry
Ahh. I don't even know what to say. These two getting together was one of the most satisfying endings I've ever seen and they are a wonderfully perfect couple. They are two of the most realistic characters I've ever witnessed and watching them be happy is extremely important to me.